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2,2,2-Trifluoroethanol, 99+%, Thermo Scientific Chemicals

Product Code. 11499702
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Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.

Solubility
Miscible with water, ethers, ketones, alcohols and chloroform.

Notes
Moisture sensitive.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 75-89-8
Molecular Formula C2H3F3O
Molecular Weight (g/mol) 100.04
MDL Number MFCD00004672
InChI Key RHQDFWAXVIIEBN-UHFFFAOYSA-N
Synonym trifluoroethanol, ethanol, 2,2,2-trifluoro, 2,2,2-trifluoroethan-1-ol, fluorinol 85, 2,2,2-trifluoroethyl alcohol, trifluoroethyl alcohol, trifluoro ethanol, tfe, perfluoro-1,1-dihydroethanol, tfetoh
PubChem CID 6409
ChEBI CHEBI:42330
SMILES OCC(F)(F)F

Specifications

Melting Point -44°C
Density 1.391
Boiling Point 74°C to 75°C
Flash Point 29°C (84°F)
Linear Formula CF3CH2OH
Refractive Index 1.29
Quantity 50 g
UN Number UN1992
Beilstein 1733203
Solubility Information Miscible with water,ethers,ketones,alcohols and chloroform.
IUPAC Name 2,2,2-trifluoroethan-1-ol
Formula Weight 100.04
Percent Purity ≥99%
Chemical Name or Material 2,2,2-Trifluoroethanol
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RUO – Research Use Only

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