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2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals Product Code.: 11986251
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2-Mercapto-1-methylimidazole, 98%, Thermo Scientific Chemicals

Product Code. 11986251
500 g, Glass Bottle
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500 g
Packaging:
Glass Bottle
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Product Code. 11986251

Brand: Thermo Scientific Acros 125505000

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Description

2-Mercapto-1-methylimidazole, CAS # 60-56-0, also known as methimazole, is a thyroid hormone antagonist used to study the treatment of thyroid disorders.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • 2-Mercapto-1-methylimidazole, also known as methimazole, is an antithyroid medication
  • Methimazole works by inhibiting the enzyme thyroid peroxidase (TPO), which is responsible for synthesizing the thyroid hormones triiodothyronine (T3) and thyroxine (T4) from the precursor thyroglobulin

Applications

  • Methimazole has been used in laboratory settings to model olfactory epithelial degeneration
  • May be used to study disruptions in iodide metabolism
  • Methimazole has been used in Pharmacokinetics studies in the laboratory
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 60-56-0
Molecular Formula C4H6N2S
Molecular Weight (g/mol) 114.17
MDL Number MFCD00179321
InChI Key PMRYVIKBURPHAH-UHFFFAOYSA-N
Synonym methimazole, thiamazole, 2-mercapto-1-methylimidazole, tapazole, mercazolyl, 1-methylimidazole-2-thiol, mercazole, metazolo, methimazol, thiamazolShow MoreShow Less
PubChem CID 1349907
ChEBI CHEBI:50673
IUPAC Name 3-methyl-1H-imidazole-2-thione
SMILES CN1C=CNC1=S

Specifications

Melting Point 140.0°C to 145.0°C
Color White to Cream
Boiling Point 280.0°C
Flash Point >100°C
Loss on Drying 1% (105°C, 2 hrs) max.
Infrared Spectrum Authentic
Assay Percent Range 98%
Packaging Glass Bottle
Quantity 500 g
Beilstein 24,17
Merck Index 15,6043
Solubility Information Solubility in water: soluble. Other solubilities: soluble in ethanol and acetone,sparingly soluble in ether,petr. ether,benzene
Formula Weight 114.16
Percent Purity 98%
Physical Form Crystalline Powder
Chemical Name or Material 2-Mercapto-1-methylimidazole
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4 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberA0460299 Certificate TypeCertificate of Analysis Date26/02/2024 Catalog Number125501000,125500250,125505000
Lot NumberA0395038 Certificate TypeCertificate of Analysis Date12/12/2022 Catalog Number125501000,125500250,125505000
Lot NumberA0408789 Certificate TypeCertificate of Analysis Date28/11/2022 Catalog Number125501000,125500250,125505000
Lot NumberA0442333 Certificate TypeCertificate of Analysis Date23/05/2022 Catalog Number125501000,125500250,125505000

Safety and Handling

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Product Identifier
  • 2-Mercapto-1-methylimidazole
 Signal Word
  • Warning
 Hazard Category
  • Reproductive toxicity Category 2
  • Respiratory sensitiser Category 1
 Hazard Statement
  • H361fd-Suspected of damaging fertility. Suspected of damaging the unborn child.
  • H317-May cause an allergic skin reaction.
 Precautionary Statement
  • P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
  • P272-Contaminated work clothing should not be allowed out of the workplace.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
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RUO – Research Use Only

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