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STEMCELL Technologies 3-Deazaneplanocin A
Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase
Brand: STEMCELL Technologies 72324
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Description
- Deazaneplanocin A (DZNep) is an inhibitor of lysine methyltransferases, particularly EZH2
- DZNep therefore acts as an epigenetic modifier, specifically inhibiting the trimethylation of Histone 3, Lysine 27, by depleting levels of EZH2
- (Miranda et al.), Tan et al.), Tseng et al.)
- Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, VaLproic Acid, Tranylcypromine, and E-616452, by increasing OCT4 expression at later stages of reprogramming (Hou et al.)
- Reactivation of XIST-dependent inactive X chromosomes in human embryonic stem cells (Diaz Perez et al.)
- Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.)
- Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.)
Specifications
| 102052-95-9 | |
| 1 mg | |
| ≥98% |
| DZNep; NSC 617989 | |
| C12H14N4O3 |
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