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  6. Amphotericin B, Streptomyces nodosus, Thermo Scientific Chemicals

Amphotericin B, Streptomyces nodosus, Thermo Scientific Chemicals

Product Code. 15454089
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Quantity:
1 g

Description

Amphotericin B, CAS # 1397-89-3, is an antifungal that has been used against fungus caused by protozoan parasites of Leishmania genus.

Amphotericin B, antifungal activity has been used against leishmaniasis caused by protozoan parasites of the Leishmania genus. Amphotericin B trihydrate was observed to cause suppression of bone marrow progenitor cells and to induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Amphotericin B is an antibiotic that has antifungal activity and is produced mainly by Streptomyces nodosus
Applications
• It has antifungal activity against fungus caused by protozoan parasites of Leishmania genus by binding to an essential component of the fungal cell membrane and altering cell membrane permeability
• It can suppress bone marrow progenitor cells and induce Actinomycin D(CR001) sensitivity in drug resistant HELA cells in vitro
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1397-89-3
Molecular Formula C47H73NO17
Molecular Weight (g/mol) 924.09
MDL Number MFCD00877763
InChI Key APKFDSVGJQXUKY-ZNVUZQDLSA-N
PubChem CID 134129663
IUPAC Name (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19Z,21Z,23Z,25Z,27Z,29Z,31Z,33R,35S,36R,37S)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
SMILES C[C@H]1O[C@@H](O[C@@H]2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(O)=O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C/C=C\C=C/C=C\C=C/C=C\C=C/2)[C@@H](O)[C@@H](N)[C@@H]1O

Specifications

Type Amphotericin B
Physical Form Powder
Beilstein 78342
Merck Index 14,585
Solubility Information Soluble in aqueous buffers at pH 2;0 or 11;0; Insoluble at pH 6;0-7;0; Also soluble in DMSO or DMF
Formula Weight 924.1
Color Yellow
Quantity 1 g
Sensitivity Light and moisture sensitive
Chemical Name or Material Amphotericin B, Streptomyces nodosus

RUO – Research Use Only

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