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v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian), Mouse, Polyclonal Antibody, Abnova™

Mouse polyclonal antibody raised against a partial recombinant ERBB2.

Brand:  Abnova H00002064-A01.50uL

Product Code. 16177754

  • 242.00 € / 50µL

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Description

Description

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq

Sequence: STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGD
Specifications

Specifications

v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Polyclonal
Mouse polyclonal antibody raised against a partial recombinant ERBB2.
ERBB2
CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Mouse
50 μL
Primary
Human
Serum
ELISA, Western Blot
Unconjugated
50% glycerol
NM_004448
ERBB2
ERBB2 (NP_004439, 22 a.a. ∼ 121 a.a) partial recombinant protein with GST tag.
RUO
2064
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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