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ID2 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA532449
This item is not returnable.
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Description
Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is breast carcinoma.
Inhibitor of differentiation (ID) proteins are transcriptional modulators that control differentiation and cell cycle progression in organisms ranging from flies to humans, and belong to a protein family characterized by a helix-loop-helix (HLH) region, but lacking the basic amino acid domain required to bind to DNA. ID2, but not its family members ID1 or ID3, can disrupt the antiproliferative effects of retinoblastoma (Rb) family tumor suppressor proteins, thereby allowing progression of the cell cycle.
Specifications
| ID2 | |
| Polyclonal | |
| ID2 | |
| GIG8, ID2A, ID2H, bHLHb26, DNA-binding protein inhibitor ID-2, DNA-binding protein inhibitor ID2, cell growth-inhibiting gene 8, class B basic helix-loop-helix protein 26, helix-loop-helix protein ID2, inhibitor of differentiation 2 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 15902, 3398 | |
| -20°C | |
| Liquid |
| Immunohistochemistry (Paraffin) | |
| Unconjugated | |
| P41136, Q02363 | |
| ID2 | |
| Synthetic peptide from C-terminus of human ID2 protein. | |
| 500 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |