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  8. Apoptosis Activator 2, Tocris Bioscience™

Apoptosis Activator 2, Tocris Bioscience™

Product Code. 18025102
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Quantity:
10 mg
50 mg
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Description

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 > 40 μM).

Chemical Identifiers

CAS 79183-19-0
Molecular Formula C15H9Cl2NO2
Molecular Weight (g/mol) 306.14
MDL Number MFCD00141556
InChI Key KGRJPLRFGLMQMV-UHFFFAOYSA-N
Synonym apoptosis activator 2, apoptosis activator ii, 1-3,4-dichlorobenzyl-1h-indole-2,3-dione, 1-3,4-dichlorobenzyl indoline-2,3-dione, 1-3,4-dichlorophenyl methyl indole-2,3-dione, 1h-indole-2,3-dione,1-3,4-dichlorophenyl methyl, apoptosisactivator2, tocris-2098, cbmicro_042945, d07edg
PubChem CID 1901244
IUPAC Name 1-[(3,4-dichlorophenyl)methyl]-2,3-dihydro-1H-indole-2,3-dione
SMILES ClC1=CC=C(CN2C(=O)C(=O)C3=CC=CC=C23)C=C1Cl

Specifications

Quantity 10 mg
Formula Weight 306.14
Percent Purity >99%
Chemical Name or Material Apoptosis Activator 2
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