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Tocris Bioscience™ AZD 7648
Potent and selective DNA-PK inhibitor
Brand: Tocris Bioscience™ 7825/10
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Description
AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable.Specifications
| 7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one | |
| 10 mg | |
| C18H20N8O2 |
| 2230820-11-6 | |
| DNA-dependent Protein Kinase Inhibitors |
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