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  8. BMS 265246, >97%, Tocris Bioscience™

BMS 265246, >97%, Tocris Bioscience™

Product Code. 30000968
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Quantity:
10 mg
50 mg
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Description

Potent cdk1/2 inhibitor

Potent cyclin-dependent kinase 1 (cdk1) and cdk 2 inhibitor (IC50 values are 5.6 - 71 and 6 - 14 nM, respectively). Also inhibits cdk4 and cdk5 in the sub micromolar range and cdk7 and cdk9 in the low micromolar range. Inhibits proliferation of HCT-116 colon cancer cells in vitro.

Chemical Identifiers

CAS 582315-72-8
Molecular Formula C18H17F2N3O2
Molecular Weight (g/mol) 345.35
InChI Key SCFMWQIQBVZOQR-UHFFFAOYSA-N
Synonym unii-4gf4a623rf, 4-butoxy-1h-pyrazolo 3,4-b pyridin-5-yl-2,6-difluoro-4-methylphenyl methanone, 4-butoxy-5-2,6-difluoro-4-methylbenzoyl-1h-pyrazolo 3,4-b pyridine, d05szh, 4-butoxy-1h-pyrazolo 3,4-b pyridin-5-yl 2,6-difluoro-4-methylphenyl methanone, methanone, 4-butoxy-1h-pyrazolo 3,4-b pyridin-5-yl 2,6-difluoro-4-methylphenyl, 4-butoxy-1h-pyrazolo 3,4-b pyridin-5-yl 2,6-difluoro-4-methylphenyl-methanone, 4-butoxy-5-2,6-difluoro-4-methylphenyl carbonyl-1h-pyrazolo 3,4-b pyridine
PubChem CID 5329775
IUPAC Name (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)-(2,6-difluoro-4-methylphenyl)methanone
SMILES CCCCOC1=C2C=NNC2=NC=C1C(=O)C3=C(C=C(C=C3F)C)F

Specifications

Linear Formula C18H17F2N3O2
Quantity 10 mg
Solubility Information Soluble to 50mM in DMSO
Formula Weight 345.34
Chemical Name or Material (4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl) (2,6-difluoro-4-methylphenyl)methanone
Grade >97%
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