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Carbonic Anhydrase IX Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA5120463
This item is not returnable.
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Description
Positive test controls include: Mouse liver, Rat liver. The target is usually found in the following locations: Cell membrane, Cell projection, Nucleus, Single-pass type I membrane protein, microvillus membrane, nucleolus. Immunogen sequence: GSSGEDDPLG EEDLPSEEDS PREEDPPGEE DLPGEEDLPG EEDLPEVKPK SEEEGSLKLE DLPTVEAPGD PQEPQNNAHR DKEGDDQSHW RYGGDPPWPR
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.Specifications
Carbonic Anhydrase IX | |
Polyclonal | |
Unconjugated | |
Car9 | |
Ca9; CA-9; CAIX; CA-IX; Car9; Carbonate dehydratase IX; carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; G250; Membrane antigen MN; membrane antigen MN homolog; MN; MN/CA9; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; renal cell carcinoma-associated antigen G250 | |
Rabbit | |
Affinity Chromatography | |
RUO | |
230099, 313495 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.81 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
Q8VHB5 | |
Car9 | |
Recombinant fusion protein containing a sequence corresponding to amino acids 52-151 of human Carbonic Anhydrase 9 (CA9/G250) (NP_001207.2). | |
100 μL | |
Primary | |
Mouse, Rat | |
Antibody | |
IgG |