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CVT 313, Tocris Bioscience™

Product Code. 30000901
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

cdk2 inhibitor

Cyclin-dependent kinase 2 (cdk2) inhibitor (reported IC50 values are 0.18 to 0.5 μM). Also inhibits cdk5 in sub-micromolar range (IC50 = 0.42 μM). Displays >7-fold selectivity for cdk2 and cdk5 over other cdks. Inhibits proliferation rat neonatal aortic smooth muscle cells and a range of tumor cells lines in vitro. Inhibits restenosis in a rat carotid artery injury model.

Chemical Identifiers

CAS 199986-75-9
Molecular Formula C20H28N6O3
Molecular Weight (g/mol) 400.48
MDL Number MFCD06411412
InChI Key NQVIIUBWMBHLOZ-UHFFFAOYSA-N
Synonym CVT 313
PubChem CID 6918386
IUPAC Name 2-[(2-hydroxyethyl)(6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl)amino]ethan-1-ol
SMILES COC1=CC=C(CNC2=C3N=CN(C(C)C)C3=NC(=N2)N(CCO)CCO)C=C1

Specifications

Linear Formula C20H28N6O3
Quantity 50 mg
Solubility Information Soluble to 100mM in DMSO and to 100mM in ethanol
Formula Weight 400.47
Percent Purity >98%
Physical Form Solid
Chemical Name or Material 2,2'-[[6-[[(4-Methoxyphenyl)methyl]amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis[ethanol]
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