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Thermo Fisher Scientific DDM/CHS Solution (10:1)

A ready-to-use solution for solubilization of membrane proteins while maintaining structural integrity and activity.

Brand: Thermo Fisher Scientific A50942

161.50 EUR valid until 2024-12-31
Use promo code "21665" to get your promotional price.

Product Code. 17439292

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For Research Use Only. All usage must comply with product instructions.

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Description

A ready-to-use solution for solubilization of membrane proteins while maintaining structural integrity and activity
The stable pre-formulated solution contains a mixture of dodecyl-β-D-maltoside (DDM) (100 mg/mL) and cholesteryl hemisuccinate (CHS) (10 mg/mL) in deionized water with final concentrations of 10% and 1%, respectively
Typical working concentrations are 1% DDM/0.1% CHS for protein extraction and 0.1% DDM/0.01% CHS for protein purification

Features of DDM/CHS Solution include:

Ready-to-use liquid formulation
Mixture of nonionic detergent, DDM, with dual hydrophobic/hydrophilic properties and anionic detergent, CHS, that aids in the stabilization of large unilamellar vesicles
DDM/CHS micelles aid in solubilization of membrane proteins while preserving structure and function
Suitable for protein solubilization and stabilization for single particle cryo-EM analysis

Properties of DDM:

Molecular formula: C₂₄H₄₆O₁₁
Molecular weight: 510.6 g/mol
Detergent class: Non-ionic
Micelle molecular weight: 50,000 g
Critical micelle concentration (CMC): 0.17 mM (0.009% w/v) in water; 0.12 mM (0.006% w/v) in 0.2 M NaCl

Properties of CHS:

Specifications

Form	Liquid
Quantity	10 x 1 mL

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