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STEMCELL Technologies EC23

Retinoid pathway activator; Activates retinoic acid receptor (RAR)

Brand: STEMCELL Technologies 73104

Product Code. 17150172

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Description

EC23 is a retinoic acid receptor (RAR) agonist with pan-RAR activity (EC₅₀: RARα 41 nM, RARβ 0.5 nM, RARγ 0.4 nM), while having no appreciable activity for retinoid X receptors (RXR; EC₅₀> 10μM for all; Gambone et al.) It is a photostable synthetic analog of all-trans retinoic acid (ATRA; Christie et al. 2008)
EC23 also weakly activates aryl hydrocarbon receptor (Gambone et al.)
Induces neural differentiation of human pluripotent stem cells, similarly to ATRA (Christie et al. 2010; Clemens et al.)
Induces neuronal differentiation of human fetal neural progenitor cell line ReNcell 197VM (Christie et al. 2010)

Specifications

Synonym	AGN 190205; BASF 46928
Molecular Formula	C₂₃H₂₄O₂

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