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  6. Estrone, 99+%, Thermo Scientific Chemicals

Estrone, 99+%, Thermo Scientific Chemicals

Product Code. 10764031
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Quantity:
1 g
5 g
25 g
Packaging:
Glass bottle
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This item is not returnable. View return policy

Description

Estrone, 99%, CAS#53-16-7, is one of the major mammalian estrogen, is a steroid and a sex hormone. It is synthetized from cholesterol and secreted mainly from the gonads. It also presents antineoplastic and bone density conservative activities.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Estrone is an aromatized C18 steroid considered one of the major mammalian estrogen and a sex hormone. It shows antineoplastic and bone density conservative activities.

• This compound can interact with estrogen receptors in target tissues to produce similar effects to estradiol. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes.

Applications

• Estrone has the ability to increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins.

• It can suppress the release of follicle-stimulating hormone and luteinizing hormone.

• This compound can be produced from androstenedione or testosterone via estradiol. In vivo, it can be generated mainly in the ovaries, placenta, and peripheral tissues (especially adipose tissue) through conversion of androstenedione. It may be metabolized to 16-α-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.

• It has been used as medium supplement for hormone-based degranulation studies of natural killer cells.

• It is used as medium component for monitoring fatty acid synthase activity in breast adenocarcinoma cell lines.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 53-16-7
Molecular Formula C18H22O2
Molecular Weight (g/mol) 270.36
InChI Key DNXHEGUUPJUMQT-CBZIJGRNSA-N
Synonym estrone, folliculin, oestrone, theelin, estrovarin, estrugenone, follicular hormone, kestrone, estron, follicunodis
PubChem CID 5870
ChEBI CHEBI:17263
IUPAC Name (8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one
SMILES CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)O

Specifications

Melting Point 258.0°C to 261.0°C
Color White
Loss on Drying 0.5% max. (105°C, 3 hrs)
Infrared Spectrum Authentic
Assay Percent Range 99% min. (on dried substance) (HPLC)
Packaging Glass bottle
Quantity 1 g
Merck Index 15,3763
Specific Rotation Condition + 158.00 (20.00°C c=1,dioxane)
Specific Rotation + 158.00
Solubility Information Solubility in water: 0.03g/L.
Formula Weight 270.36
Clarity passes test
Percent Purity 99+%
Physical Form Crystalline Powder or Crystals
Chemical Name or Material Estrone
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Safety and Handling

compliance-icons
Product Identifier
  • Estrone
 Signal Word
  • Danger
 Hazard Category
  • Carcinogenicity Category 2
  • Reproductive toxicity on or via lactation
  • Reproductive toxicity Category 1A
 Hazard Statement
  • H351-Suspected of causing cancer.
  • H360FD-May damage fertility. May damage the unborn child.
  • H362-May cause harm to breast-fed children.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only

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