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Ethyl carbazate, 97%, Thermo Scientific Chemicals
Description
Prepare 4-phenylurazole from ethyl carbazate and then oxidize the urazole with gaseous dinitrogen tetroxide to yield 4-phenyl-1,2,4-tri- azoline-3,5-dione la. Modification of the ethyl carbazate procedure in which analytically pure monoalkylhydrazine hydrochlorides were isolated in greater than 90% yield, starting from a ketone or aldehyde. Treatment of primary amines is with chloroamine or hydroxylamine-0-sulfonic acid and the condensation of a carbonyl compound with ethyl carbazate. The FeCl 3 -catalyzed reaction of ethyl carbazate (2 b) proceeded readily to give β-hydroxyester 3 b in better yield. A new one-pot neat synthesis of some 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones through cyclocondensation of ethyl carbazate with aryl nitriles catalyzed by DMAP as an efficient and basic nucleophilic catalyst is described.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Prepare 4-phenylurazole from ethyl carbazate and then oxidize the urazole with gaseous dinitrogen tetroxide to yield 4-phenyl-1,2,4-tri- azoline-3,5-dione la. Modification of the ethyl carbazate procedure in which analytically pure monoalkylhydrazine hydrochlorides were isolated in greater than 90% yield, starting from a ketone or aldehyde. Treatment of primary amines is with chloroamine or hydroxylamine-0-sulfonic acid and the condensation of a carbonyl compound with ethyl carbazate. The FeCl 3 -catalyzed reaction of ethyl carbazate (2 b) proceeded readily to give β-hydroxyester 3 b in better yield. A new one-pot neat synthesis of some 5-aryl-2,4-dihydro-3H-1,2,4-triazol-3-ones through cyclocondensation of ethyl carbazate with aryl nitriles catalyzed by DMAP as an efficient and basic nucleophilic catalyst is described.
Solubility
Very soluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.
Specifications
Specifications
| Melting Point | 44°C to 47°C |
| Boiling Point | 85°C to 86°C (7 mmHg) |
| Flash Point | 86°C (186°F) |
| Quantity | 1000 g |
| UN Number | UN2811 |
| Beilstein | 878265 |
| Sensitivity | Moisture sensitive |
| Solubility Information | Very soluble in water. |
| Formula Weight | 104.11 |
| Percent Purity | 97% |
| Show More |
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Certificates
Certificates
A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.
| Lot Number | Certificate Type | Date | Catalog Number |
|---|---|---|---|
| 10253066 | Certificate of Analysis | 28/11/2024 | A13860.18,A13860.0B,A13860.30 |
| 10251974 | Certificate of Analysis | 26/08/2024 | A13860.18,A13860.0B,A13860.30 |
| 10220090 | Certificate of Analysis | 05/12/2023 | A13860.18,A13860.0B,A13860.30 |
| 10213990 | Certificate of Analysis | 05/12/2023 | A13860.18,A13860.0B,A13860.30 |
| 10231512 | Certificate of Analysis | 05/12/2023 | A13860.18,A13860.0B,A13860.30 |
Safety and Handling
- Ethyl carbazate
- Warning
- Acute toxicity Category 3
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity after repeated exposure Category 2
- Specific target organ toxicity Category 3
- H301-Toxic if swallowed.
- H311-Toxic in contact with skin.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H335-May cause respiratory irritation.
- H373-May cause damage to organs.
- P260-Do not breathe dust/fume/gas/mist/vapours/spray.
- P270-Do not eat, drink or smoke when using this product.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P314-Get medical advice/attention if you feel unwell.
- MIXTURE LIST-Contains : Hydrazinecarboxylicacid, ethyl ester
RUO – Research Use Only
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