missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Biochemical Reagents
  4. Peptides
  5. 10434095

Invitrogen™ FL - SRC 3-1 Peptide, 100μM

Contains known interaction motifs and labeled with fluorescein. Invitrogen™ Fluorescein-SRC 3-1 Peptide, 100μM is matched to complement the LanthaScreen™ TR-FRET Nuclear Receptor Coregulator Assays to enable primary or secondary screening of nuclear receptor agonists and antagonists.

Brand:  Invitrogen™ PV4590

Product Code. 10434095

  • 191.00 € / Each

Please to purchase this item. Need a web account? Register with us today!

Explore more special offers

For Research Use Only. All usage must comply with product instructions.

This item is not returnable. View return policy

Description

Description

Ligand binding to nuclear receptors causes conformational changes in the receptor, resulting in a cascade of events, including dissociation of repressor proteins, association of coactivator proteins, and assembly of pol II and other transcriptional factors for activation of target genes. TR-FRET based assays can be developed using the LanthaScreen™ panel of fluorescein-labeled coregulator peptides to investigate conformational changes of nuclear receptors upon ligand binding, either by determining the affinity of ligand-bound receptor for different coregulator peptides, or by identifying additional agonists or antagonists via displacement or recruitment of a specific coregulator peptide.

In the LanthaScreen™ TR-FRET RXR beta Coactivator Assay, a terbium (Tb)-labeled anti-GST antibody is used to indirectly label GSTtagged RXR beta protein. An agonist (9-cis Retinoic Acid) added to the receptor which, upon ligand binding, causes a conformational change resulting in recruitment of the Fl-D22 coactivator peptide. The binding of the fluorescent coregulator peptide to RXR beta causes an increase in the TR-FRET emission ratio.

TRUSTED_SUSTAINABILITY
Specifications

Specifications

Store in freezer (-5 to -30°C).
Classic Dyes
100 μL
Dry Ice
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates

Certificates

A lot number is required to show results for certificates. To find your lot number on previous orders use our order status area.

5 results found
Lot Number Certificate Type Date Catalog Number
Lot Number1899812J Certificate TypeCertificate of Analysis Date21/02/2025 Catalog NumberPV4590
Lot Number1899812H Certificate TypeCertificate of Analysis Date19/05/2023 Catalog NumberPV4590
Lot Number1899812G Certificate TypeCertificate of Analysis Date09/10/2021 Catalog NumberPV4590
Lot Number1899812F Certificate TypeCertificate of Analysis Date23/02/2020 Catalog NumberPV4590
Lot Number1899812E Certificate TypeCertificate of Analysis Date07/08/2019 Catalog NumberPV4590
Promotions

Promotions

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title
Invitrogen™ FL - SRC 3-1 Peptide, 100μM > 100μL

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.

For Research Use Only. Not for use in diagnostic procedures.