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GSK 690693, Tocris Bioscience™

Product Code. 18045322
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10mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Akt kinase inhibitor. Antitumor

ATP-competitive pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively). Also exhibits some inhibition for AMPK, PKA and PAK and PKC isoforms (IC50 < 100 nM). Displays antiproliferative and apoptotic effects in tumor cell lines.

Specifications

CAS 937174-76-0
Molecular Formula C21H27N7O3
Quantity 10 mg
Synonym unii-gwh480321b, s-4-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-7-piperidin-3-ylmethoxy-1h-imidazo 4,5-c pyridin-4-yl-2-methylbut-3-yn-2-ol, compound 3g pmid 18800763, 4-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-7-3s-3-piperidinylmethoxy-1h-imidazo 4,5-c pyridin-4-yl-2-methyl-3-butyn-2-ol, 4-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-7-3s-piperidin-3-ylmethoxy-1h-imidazo 4,5-c pyridin-4-yl-2-methylbut-3-yn-2-ol, 4-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-7-3s-piperidin-3-ylmethoxy imidazo 4,5-c pyridin-4-yl-2-methylbut-3-yn-2-ol, r-4-2-4-amino-1,2,5-oxadiazol-3-yl-1-ethyl-7-piperidin-3-ylmethoxy-1h-imidazo 4,5-c pyridin-4-yl-2-methylbut-3-yn-2-ol, d0ms3z, gsk hplc
InChI Key KGPGFQWBCSZGEL-ZDUSSCGKSA-N
SMILES CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N
IUPAC Name 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3S)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol
Molecular Weight (g/mol) 425.493
PubChem CID 16725726
Formula Weight 425.48
Percent Purity >98%
Chemical Name or Material GSK 690693
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