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Invitrogen™ Human ErbB2 (HER-2) Fc Chimera Recombinant Protein

Product Code. 17946331
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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Product Code. 17946331

Brand: Invitrogen™ RP88054

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This item is not returnable. View return policy

Descripción

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (1695 μL) be added to the vial to prepare a stock solution of 0.83 mg/mL. Concentration is measured by UV.

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
TRUSTED_SUSTAINABILITY

Especificaciones

Accession Number P04626
Concentration 0.25 mg/mL
For Use With (Application) Control, Binding Assay, Bioactivity
Format Lyophilized
Formulation PBS with 5% mannitol, 5% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Gene ID (Entrez) 2064
Molecular Weight (g/mol) 96.09 kDa
Name Human ErbB2 (HER-2) Fc Chimera
pH Range 7.4
Purification Method Purified
Quantity 100 μg
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Endotoxin Concentration <1.0 EU/μg
Gene Alias avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); CD antigen CD340; CD340; c-erb B2/neu protein; c-erbB2; C-erbB-2; c-neu; epidermal growth factor receptor-related protein; erbb 2; ERBB2; erb-b2; Erbb-2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; erb-b2 receptor tyrosine kinase 2; her 2; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; Kiaa3023; metas; Metastatic lymph node gene 19 protein; mKIAA3023; MLN 19; MLN19; NEU; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; p185erbB2; p185neu; phospho ErbB2; proto-oncogene c-ErbB-2; Proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene 2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Common Name Her-2 (ErbB2)
Gene Symbol ERBB2
Biological Activity 1. Immobilized Her2/ERBB2 Protein, Human, Recombinant (ECD, hFc Tag) (at 2 μg/ml (100 μL/well) can bind Anti-Erbb2 Antibody (Trastuzumab), the EC50 is 16-80 ng/mL 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 μg/mL in the presence of 0.6 μg/mL Anti-ErbB2/Her2 Monoclonal Antibody.)
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag
Sequence Human ErbB2, amino acids Met1-Thr652 (Accession # NP_004439.2) with a C-terminal human IgG1 Fc region
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Activity Immobilized Recombinant Human HER2 / ErbB2 Protein (Fc Tag) (Cat: 10004-H02H) at 0.05 μg/mL (100 μL/well) can bind Trastuzumab derived Anti-Erbb2 antibody, Human IgG1, the EC50 is 10.2-30.8 ng/mL (QC tested).
Expression System HEK293 cells
Form Lyophilized
Purity or Quality Grade ≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.
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