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Gibco™ Human Noggin Recombinant Protein, PeproTech®
Recombinant Protein
Brand: Gibco™ 120-10C-100UG
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Description
120-10C-1MG will be provided as 2 x 500 μg (120-10C-500UG). Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains. Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
Specifications
| Q13253 | |
| protein with no preservative | |
| 46 kDa | |
| 100 μg | |
| RUO | |
| NOG; Noggin; Noggin precursor; noggin; LOW QUALITY PROTEIN: noggin; SYM1; symphalangism 1 (proximal); SYNS1; SYNS1A | |
| NOG | |
| Unconjugated | |
| QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC | |
| HEK293 cells | |
| ≥ 95% by SDS-PAGE gel and HPLC analyses. |
| Functional Assay | |
| 9241 | |
| Human Noggin | |
| HEK293 cells | |
| <1 EU/ μg | |
| Noggin | |
| Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin. | |
| Recombinant | |
| -20°C | |
| Lyophilized |
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Product Title
Gibco™ Human Noggin Recombinant Protein, PeproTech® > 100 μg; Unlabeled
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