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Gibco™ Human TGF-beta 1 Recombinant Protein, PeproTech®

CHO cells Recombinant Protein

80.00 € - 5140.00 €

Specifications

Accession Number P01137
For Use With (Application) Functional Assay
Gene ID (Entrez) 7040
Molecular Weight (g/mol) 25
Name Human TGF-beta 1
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Products 8
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17861433
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Gibco™
100-21C-100UG
100 μg
1030.00 €
100µg
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17821343
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Gibco™
100-21C-10UG
10 μg
194.00 €
10µg
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30089692
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Gibco™
100-21C-01M
2 x 500 μg
5140.00 €
Pack of 2
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17860933
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Gibco™
100-21C-1MG
2 x 500 μg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
N/A
17840273
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Gibco™
100-21C-250UG
250 μg
1802.00 €
250µg
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17889892
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Gibco™
100-21C-2UG
2 μg
80.00 €
2µg
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17891433
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Gibco™
100-21C-500UG
500 μg
3085.00 €
500µg
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17881443
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Gibco™
100-21C-50UG
50 μg
620.00 €
50µg
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Description

Description

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.
Specifications

Specifications

P01137
7040
Human TGF-beta 1
-20°C
<1 EU/μg
Tgfb1
Unconjugated
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
≥ 98% by SDS-PAGE gel and HPLC analyses.
Functional Assay
25
CHO cells
RUO
CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF ß; TGF ß 1; TGF ß1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFß1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor ß1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
Human
Recombinant
Lyophilized
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