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IEM 1460, Tocris Bioscience™

Product Code. 30002127
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Open-channel blocker of AMPA currents; selective for non-GluA2-containing receptors

Voltage-dependent open-channel blocker of AMPA receptors. Selective for GluR2 subunit-lacking (Ca2+-permeable) receptors over GluA2-containing receptors (IC50 values are 2.6 and 1102 μM, respectively). Selectively blocks fast spiking interneuron but not medium spiny projection neuron in mouse striatum. Also blocks NMDA receptor-mediated currents. Anticonvulsant in vivo.

Chemical Identifiers

CAS 121034-89-7
Molecular Formula C19H38Br2N2
Molecular Weight (g/mol) 454.335
InChI Key CQTDZUSQSTUZDA-UHFFFAOYSA-M
Synonym tocris-1636, 5-1-adamantylmethylamino pentyl-trimethylazanium bromide hydrobromide, 5-adamantan-1-ylmethyl amino pentyl trimethylazanium hydrobromide bromide, n,n,h,-trimethyl-5-tricyclo 3.3.1.13,7 dec-1-ylmethyl amino-1-pentanaminiumbromide hydrobromide
PubChem CID 6604954
IUPAC Name 5-(1-adamantylmethylamino)pentyl-trimethylazanium;bromide;hydrobromide
SMILES C[N+](C)(C)CCCCCNCC12CC3CC(C1)CC(C3)C2.Br.[Br-]

Specifications

Quantity 10 mg
Formula Weight 454.33
Percent Purity >98%
Chemical Name or Material IEM 1460
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