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Thermo Scientific Chemicals Itraconazole, 99% Product Code.: 15279786
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Thermo Scientific Chemicals Itraconazole, 99%

Product Code. 15279786
5 g
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5 g
25 g
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Product Code. 15279786

Brand: Thermo Scientific Chemicals 452870050

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Description

Itraconazole, or voriconazole, CAS # 84625-61-6, is an N-arylpiperazine that has antifungal properties.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Itraconazole is an aromatic ether that works as a strong inhibitor of P-glycoproteins and CYP3A4

• Itraconazole also acts as a hedgehog signaling inhibitor and P450 inhibitor

Applications

• Itraconazole can be exhibits antifungal activity against organisms including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis

• Itraconazole may be used to experimentally target the delivery of other molecules, such as plasmids, to cells

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 84625-61-6
Molecular Formula C35H38Cl2N8O4
Molecular Weight (g/mol) 705.64
MDL Number MFCD00870168,MFCD00941396
InChI Key VHVPQPYKVGDNFY-ZPGVKDDISA-N
Synonym itraconazole-d5, itraconazole, oriconazole-d5, triasporin-d5, sporamelt-d5, itrizole-d5, sporanox-d5, +/--4-4-4-4-2r,4s-2,4-dichlorophenyl-2-1h-1,2,4-triazol-1-ylmethyl-1,3-dioxolan-4-yl methoxy phenyl-1-piperazinyl phenyl-2,4-dihydro-2-1-methylpropyl-d5-3h-1,2,4-triazol-3-one, 2h5-4-4-4-4-2-1h-1,2,4-triazol-1-yl methyl-2-2,4-dichlorophenyl-1,3-dioxolan-4-yl methoxy phenyl piperazin-1-yl phenyl-1-sec-butyl-1h-1,2,4-triazol-5 4h-one, 2-3,3,4,4,4-2 h? butan-2-yl-4-4-4-4-2r,4s-2-2,4-dichlorophenyl-2-1,2,4-triazol-1-ylmethyl-1,3-dioxolan-4-yl methoxy phenyl piperazin-1-yl phenyl-1,2,4-triazol-3-oneShow MoreShow Less
PubChem CID 45039617
IUPAC Name 4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3,3,4,4,4-pentadeuteriobutan-2-yl)-1,2,4-triazol-3-oneShow MoreShow Less
SMILES CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1

Specifications

Melting Point 168.0°C to 170.0°C
Loss on Drying 0.5% max.
Infrared Spectrum Authentic
Assay Percent Range 98.5% min. (HPLC)
Quantity 5 g
Merck Index 15,5292
Solubility Information Solubility in water: <1mg/mL. Other solubilities: solubility in ethanol: <1mg/mL, solubility in dmso: 4mg/mL
Formula Weight 705.64
Percent Purity 99%
Chemical Name or Material Itraconazole

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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberA0450186 Certificate TypeCertificate of Analysis Date02/05/2023 Catalog Number452870050,452870250
Lot NumberA0400563 Certificate TypeCertificate of Analysis Date14/12/2022 Catalog Number452870050,452870250
Lot NumberA0398764 Certificate TypeCertificate of Analysis Date14/12/2022 Catalog Number452870050,452870250
Lot NumberA0399018 Certificate TypeCertificate of Analysis Date14/12/2022 Catalog Number452870050,452870250
Lot NumberA0448248 Certificate TypeCertificate of Analysis Date13/12/2022 Catalog Number452870050,452870250

Safety and Handling

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Product Identifier
  • Itraconazole
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
  • Serious eye damage/eye irritation Category 2
  • Skin corrosion/irritation Category 2
  • Specific target organ toxicity Category 3
 Hazard Statement
  • H315-Causes skin irritation.
  • H319-Causes serious eye irritation.
  • H335-May cause respiratory irritation.
  • H302-Harmful if swallowed.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
  • P302+P352-IF ON SKIN: Wash with plenty of water/.
  • P312-Call a POISON CENTER/doctor/if you feel unwell.
  • P332+P313-If skin irritation occurs: Get medical advice/attention.
  • P337+P313-If eye irritation persists: Get medical advice/attention.
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RUO – Research Use Only

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