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  8. 18055012

J 104129 fumarate, Tocris Bioscience™

Product Code. 18055012
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Quantity:
10 mg
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This item is not returnable. View return policy

Description

Potent and selective M3 antagonist

Potent M3 muscarinic receptor antagonist that displays ∽ 120-fold selectivity over M2 receptors (Ki values are 4.2, 19 and 490 nM for human M3, M1 and M2 receptors respectively). Exhibits > 250-fold bronchial selectivity; inhibits ACh-induced bronchoconstriction but not ACh-induced bradycardia (KB values are 3.3 and 170 nM for rat trachea M3 and rat right atria M2 receptors respectively).

Specifications

CAS 257603-40-0
Molecular Formula C28H40N2O6
Quantity 10 mg
Synonym j 104129 fumarate, j104129 fumarate hplc, ?r-?-cyclopentyl-?-hydroxy-n-1-4-methyl-3-pentenyl-4-piperidinyl benzeneacetamide fumarate, alphar-alpha-cyclopentyl-alpha-hydroxy-n-1-4-methyl-3-pentenyl-4-piperidinyl benzeneacetam
InChI Key HUCQUCITPHOUAC-DSSYAJFBSA-N
SMILES CC(=CCCN1CCC(CC1)NC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.C(=CC(=O)O)C(=O)O
IUPAC Name (E)-but-2-enedioic acid;(2R)-2-cyclopentyl-2-hydroxy-N-[1-(4-methylpent-3-enyl)piperidin-4-yl]-2-phenylacetamide
Molecular Weight (g/mol) 500.636
PubChem CID 56972189
Formula Weight 500.63
Percent Purity >99%
Chemical Name or Material J 104129 fumarate
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