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J 113863, Tocris Bioscience™

Product Code. 30001443
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50 mg
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Description

Potent CCR1 chemokine receptor antagonist

Potent chemokine receptor 1 (CCR1) antagonist (IC50 values are 0.9 and 5.8 nM for human and mouse CCR1 receptors respectively). Also displays high selectivity for human but not mouse CCR3 receptors (IC50 values are 0.58 and 460 nM respectively). Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice.

Isomer also available.

Chemical Identifiers

CAS 353791-85-2
Molecular Formula C30H37Cl2IN2O2
Molecular Weight (g/mol) 655.442
InChI Key FOAFBMYSXIGAOX-UHFFFAOYSA-N
Synonym 1-cyclooct-1-en-1-yl methyl-4-2,7-dichloro-9h-xanthene-9-carbonyl amino-1-ethylpiperidin-1-ium iodide
PubChem CID 70296607
IUPAC Name 2,7-dichloro-N-[1-(cycloocten-1-ylmethyl)-1-ethylpiperidin-1-ium-4-yl]-9H-xanthene-9-carboxamide;iodide
SMILES CC[N+]1(CCC(CC1)NC(=O)C2C3=C(C=CC(=C3)Cl)OC4=C2C=C(C=C4)Cl)CC5=CCCCCCC5.[I-]

Specifications

Quantity 1 mg
Formula Weight 655.44
Percent Purity >98%
Chemical Name or Material J 113863
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