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Tocris Bioscience™ Klotho-derived peptide 1
TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction
Brand: Tocris Bioscience™ 7830/1
159.36 EUR valid until 2024-12-16
Use promo code "21630" to get your promotional price.
This item is not returnable.
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Description
Klotho-derived peptide 1 (KP1) is a peptide that binds to TGF-β receptor 2 (TβR2) (Kd = 1.4 μM). It inhibits TGF-β signaling by blocking TGF-β/TβR2 interaction. In mouse models of renal fibrosis, intravenous injection of KP1 results in its specific accumulation in the injured kidneys. It suppresses TGF-β signaling, repressing fibroblast activation and ameliorates kidney fibrosis in vivo.Specifications
| 9365 | |
| Store at -20°C | |
| M.W. (Observed): 3228.48 |
| 95% | |
| EC 3.2.1, EC 3.2.1.31, KL, klotho, TGFB2, TGFbeta, TGFbeta 2 | |
| 1 mg |