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Ko 143, Tocris Bioscience™

Product Code. 18004752
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Quantity:
1 mg
10 mg
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Description

Potent and selective BCRP inhibitor

Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance. Inhibits ABCB1 and ABCC1 at higher concentrations. Rapidly metabolized in rat plasma.

Chemical Identifiers

CAS 461054-93-3
Molecular Formula C26H35N3O5
Molecular Weight (g/mol) 469.58
MDL Number MFCD11042273,MFCD19053160
InChI Key NXNRAECHCJZNRF-UHFFFAOYNA-N
Synonym tert-butyl 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino 1',2':1,6 pyrido 3,4-b indol-3-yl propanoate, ko143 hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester hydrate, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl 1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1,2:1,6 pyrido 3,4-b indole-3-propanoic acid 1,1-dimethylethyl ester, 1,1-dimethylethyl 3s,6s,12as-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-2-methylpropyl-1,4-dioxopyrazino 1',2':1,6 pyrido 3,4-b indole-3-propanoate, 3-3s,6s-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester, 3-3s,6s,12as-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydro-pyrazino 1,2:1,6 pyrido 3,4-b indol-3-yl-propionic acid tert-butyl ester
PubChem CID 10322450
IUPAC Name tert-butyl 3-[14-methoxy-2-(2-methylpropyl)-4,7-dioxo-3,6,17-triazatetracyclo[8.7.0.0³,⁸.0¹¹,¹⁶]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate
SMILES COC1=CC=C2C(NC3=C2CC2N(C3CC(C)C)C(=O)C(CCC(=O)OC(C)(C)C)NC2=O)=C1

Specifications

Quantity 1 mg
Formula Weight 469.57
Percent Purity >99%
Chemical Name or Material Ko 143
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