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  5. STEMCELL Technologies LY411575

STEMCELL Technologies LY411575

Product Code. p-7217768
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Quantity:
5 mg
25 mg
Unit Size:
25mg
5mg
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Product Code. 17170122

Brand: STEMCELL Technologies 72792

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Description

Notch pathway inhibitor; Inhibits γ-secretase

  • LY411575 is a cell-permeable γ-secretase inhibitor (IC50 = 0.14 nM) that blocks Notch activation in vitro at 500 μM (Curry et al.; Czirr et al.) via γ-Secretase inhibition
  • Notch is a transmembrane receptor that plays a key role in cell fate decisions including cell proliferation, differentiation, and apoptosis
  • Promotes neuronal differentiation of neural progenitor cells derived from mouse embryonic stem (ES) cells (Abranches et al.; Aranha et al.)
  • Promotes goblet cell differentiation in mouse intestine and cultured colonic organoids (Okamoto et al.; Yui et al.)
  • Induces hair cell differentiation from inner ear stem cells in vitro, and transdifferentiation of supporting cells into hair cells in vivo (Bramhall et al.; Mizutari et al.)
  • Causes premature differentiation of Her4-positive progenitors into neurons in zebrafish (Dirian et al.)
  • Induces apoptosis in primary and immortalized Karposi's sarcoma cells (Curry et al.)

Specifications

CAS 209984-57-6
Quantity 5 mg
Molecular Formula C26H23F2N3O4
Purity ≥98%
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