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  7. (+)-MK 801 maleate, Tocris Bioscience™

(+)-MK 801 maleate, Tocris Bioscience™

Product Code. 18782704
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Non-competitive NMDA antagonist; acts at ion channel site

(+)-MK 801 maleate is a high affinity (Ki = 37.2 nM), selective and non-competitive NMDA receptor antagonist. (+)-MK 801 maleate acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca2+ flux. It is an effective anti-ischemic agent in several animal models. (+)-MK 801 maleate increases motor activity in rat models. (+)-MK 801 maleate inhibits proliferation and increases apoptosis in hippocampal neural stem cells (NSCs). (+)-MK 801 maleate induces schizophrenia-like symptoms in rodents.

(-)-enantiomer also available.

Chemical Identifiers

CAS 77086-22-7
Molecular Formula C20H19NO4
Molecular Weight (g/mol) 337.375
InChI Key QLTXKCWMEZIHBJ-PJGJYSAQSA-N
Synonym dizocilpine maleate, +-mk-801 hydrogen maleate, +-mk 801 maleate, dizocilpine hydrogen maleate, unii-6lr8c1b66q, dizocilpine maleate usan, dsstox_cid_25785, dsstox_rid_81126
PubChem CID 6420042
SMILES CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O

Specifications

Quantity 50 mg
Formula Weight 337.37
Percent Purity >99%
Chemical Name or Material (+)-MK 801 maleate
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