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Gibco™ Mouse Noggin Recombinant Protein, PeproTech®
Recombinant Protein
Brand: Gibco™ 250-38-20UG
172.55 EUR valid until 2025-06-30
Use promo code "24074" to get your promotional price.
Product Code. 17881873
This item is not returnable.
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Description
Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
Specifications
| P97466 | |
| protein with no preservative | |
| 46.4 kDa | |
| 20 μg | |
| RUO | |
| NOG; Noggin; Noggin precursor; noggin; LOW QUALITY PROTEIN: noggin; SYM1; symphalangism 1 (proximal); SYNS1; SYNS1A | |
| NOG | |
| Unconjugated | |
| MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC | |
| E. coli | |
| ≥ 98% by SDS-PAGE gel and HPLC analyses. |
| Functional Assay | |
| 18121 | |
| Mouse Noggin | |
| E. coli | |
| <1 EU/ μg | |
| Noggin | |
| Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin. | |
| Recombinant | |
| -20°C | |
| Lyophilized |
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Product Title
Gibco™ Mouse Noggin Recombinant Protein, PeproTech® > 20 μg; Unlabeled
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