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Invitrogen™ NIK Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA527713

Product Code. 13481867

  • 522.00 € / 100µL

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Description

Description

Recommended positive controls: A431, H1299, HeLa, HepG2, Molt-4, Raji. Predicted reactivity: Mouse (91%), Rat (93%), Rhesus Monkey (100%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

NIK
Polyclonal
Unconjugated
MAP3K14
aly; alymphoplasia; FTDCR1B; HS; HsNIK; Map3k14; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; NIK; protein kinase; serine/threonine-protein kinase NIK
Rabbit
Antigen affinity chromatography
RUO
53859, 9020
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1 mg/mL
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Q99558, Q9WUL6
MAP3K14
Recombinant protein encompassing a sequence within the N-terminus region of human MAP3K14. The exact sequence is proprietary.
100 μL
Primary
Human, Mouse
Antibody
IgG
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