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  7. P 22077, Tocris Bioscience™

P 22077, Tocris Bioscience™

Product Code. 18085222
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Quantity:
10 mg
50 mg
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Description

USP7 inhibitor

Inhibitor of ubiquitin-specific protease (USP) 7 (EC50 = 8.6 μM); also inhibits the closely related deubiquitinase (DUB) USP47. Demonstrates downstream inhibition of HDM2 and claspin in vitro. Inhibits USP7-mediated p53 deubiquitination. Blocks deubiquitination of Tip60 (KAT5) histone lysine acetyltransferase.

Chemical Identifiers

CAS 1247819-59-5
Molecular Formula C12H7F2NO3S2
Molecular Weight (g/mol) 315.31
MDL Number MFCD22580421
InChI Key RMAMGGNACJHXHO-UHFFFAOYSA-N
Synonym 1-5-2,4-difluorophenyl thio-4-nitro-2-thienyl-ethanone, 1-5-2,4-difluoro-phenylsulfanyl-4-nitro-thiophen-2-yl-ethanone, 1-5-2,4-difluorophenylthio-4-nitrothiophen-2-yl ethanone, 1-5-2,4-difluorophenyl thio-4-nitrothiophen-2-yl ethan-1-one, 1-5-2,4-difluorophenyl sulfanyl-4-nitrothiophen-2-yl ethan-1-one, 1-5-2,4-difluorophenyl sulfanyl-4-nitrothiophen-2-yl ethanone, 1-5-2,4-difluorophenyl thio-4-nitro-2-thienyl ethanon
PubChem CID 46931953
IUPAC Name 1-{5-[(2,4-difluorophenyl)sulfanyl]-4-nitrothiophen-2-yl}ethan-1-one
SMILES CC(=O)C1=CC(=C(SC2=C(F)C=C(F)C=C2)S1)[N+]([O-])=O

Specifications

Quantity 50 mg
Formula Weight 315.32
Percent Purity >99%
Chemical Name or Material P 22077
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