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R&D Systems™ Pan Caspase OPH Inhibitor Q-VD, Non-omethylated
Cell-permeable, irreversible inhibitor of caspase activity. Q-VD-OPh does not exhibit toxic effects at typical working concentrations.
Brand: R&D Systems™ OPH001-01M
This item is not returnable.
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Description
Members of the caspase gene family (cysteine proteases with aspartate specificity) play significant roles in both inflammation and apoptosis.
- The IC50 range for caspases -1, -3, -8, -9, -10, and -12 is 25 - 400 nM
- Cells that are induced to undergo apoptosis can be cultured in the presence or absence of Q-VD-OPh inhibitor
- The Caspase Inhibitor binds to the active site of activated proteases
- Treated cells can then be assayed for evidence of apoptosis inhibition by examining either whole cells or cell lysates using standard apoptosis assays
- More effective in preventing apoptosis than the widely used pan Caspase Inhibitor, ZVAD-fmk
Specifications
| Inhibitor | |
| 513.77 d | |
| Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date. | |
| 1 mg |
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