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Pemetrexed, Tocris Bioscience™

Product Code. 30000991
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART

High affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Inhibits proliferation of cancer cell lines in vitro.

Specifications

CAS 137281-23-3
Molecular Formula C20H21N5O6
Linear Formula C20H21N5O6
Quantity 50 mg
Synonym Pemetrexed
Solubility Information Soluble to 100mM in DMSO
InChI Key WBXPDJSOTKVWSJ-ZDUSSCGKSA-N
SMILES C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)NC(CCC(=O)O)C(=O)O
IUPAC Name (2S)-2-[[4-[2-(2-amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic acid
Molecular Weight (g/mol) 427.417
PubChem CID 446556
ChEBI CHEBI:63616
Formula Weight 427.41
Percent Purity >98%
Physical Form Solid
Chemical Name or Material N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid
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