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MP Biomedicals™ Pepsin
Pepsin is a peptidase used to digest proteins and is commonly used in the preparation of Fab fragments from antibodies. Pepsin, from porcine gastric mucosa, has been used to hydrolyze dry cervical samples in mice
Specifications
| Product Type | Protease |
|---|---|
| CAS | 9001-75-6 |
| For Use With (Application) | Used as a proteolytic enzyme, Used to break down the proteins into their components, i.e. peptides and aminoacids |
Description
Pepsin is a peptidase and the major proteolytic enzyme produced in the stomach. It is used to digest proteins through the cleavage of interior peptide linkages. It is commonly used in the preparation of Fab fragments from antibodies. Pepsin from porcine gastric mucosa has been used to hydrolyze dry cervical samples in mice.
- Pepsin hydrolyzes peptide bonds, not amide or ester linkages
- Pepsin cleaves peptides with an aromatic acid on either side of the peptide bond
- Sulfur-containing amino acids increase susceptibility to hydrolysis when they are close to the peptide bond
- Pepsin preferentially cleaves at the carboxyl side of phenylalanine and leucine and at the carboxyl side of glutamic acid residues
- Cleaves Phe-Val, Gln-His, Glu-Ala, Ala-Leu, Leu-Tyr, Tyr-Leu, Gly-Phe, Phe-Phe and Phe-Tyr bonds in the β chain of insulin
Specifications
| Protease | |
| 9001-75-6 | |
| Used as a proteolytic enzyme, Used to break down the proteins into their components, i.e. peptides and aminoacids |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- pepsin, 1:10,000
Signal Word
- Danger
Hazard Category
- Serious eye damage/eye irritation Category 2
- Respiratory sensitiser Category 1
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
Hazard Statement
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
- H335-May cause respiratory irritation.
Precautionary Statement
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P284-¢In case of inadequate ventilation! wear respiratory protection.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P321-Specific treatment (see on this label).
- P405-Store locked up.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : pepsin
Unless specified otherwise, for research or further manufacturing use only, not for direct human use.