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Invitrogen™ Phospho-SOX2 (Thr128) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5143771
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Description
The antibody was cross adsorbed to unphosphorylated Sox2 (Thr-128) peptide before affinity purification using phospho-Sox2 (Thr-128) peptide. This antibody detects a 34 kDa* protein on SDS-PAGE immunoblots of mouse F9 stem cells. This reactivity is not observed after lambda phosphatase dephosphorylation of Sox2.
SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.
Specifications
| Phospho-SOX2 (Thr128) | |
| Polyclonal | |
| Unconjugated | |
| SOX2 | |
| ANOP3; cb236; Delta EF2a; lcc; MCOPS3; MCOPS3 (Microphthalmia Syndromic type 3); RGD1565646; sex determining region Y-box 2; SOX 2; SOX2; Sox-2; soxp; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box 2; SOX2; SRY-box containing gene 2; SRY-box transcription factor 2; SRY-related HMG-box gene 2; transcription factor SOX2; transcription factor SOX-2; wu:fb83g04; wu:fc14d07; ysb; zgc:65860; zgc:77389 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 20674, 499593, 6657 | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
| Western Blot, Immunocytochemistry | |
| 0.5 mg/mL | |
| PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide | |
| P48431, P48432 | |
| SOX2 | |
| Phospho-Sox2 (Thr-128) synthetic peptide (coupled to carrier) corresponding to amino acids surrounding Thr-128 in mouse Sox2. This site is identical in human Sox2 (Thr-126), and has some homology with the conserved site in mouse Sox1 (Ser-136) and Sox3 (Ser-154). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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