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Thermo Scientific™ Pierce™ Iodination Reagent (1,3,4,6-tetrachloro-3α,6α-diphenyl-glycoluril)

Activate iodine for incorporation of iodine-125 labels into protein tyrosyl groups using this tetrachloro-diphenyl-glycoluril oxidizing agent.

Brand:  Thermo Scientific™ 28600

Product Code. 10404414

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Description

Description

Thermo Scientific™ Pierce Iodination Reagent is 1,3,4,6-tetrachloro-3a,6a-diphenyl-glycoluril, an oxidizing agent that efficiently activates iodine for spontaneous incorporation into protein tyrosyl groups.

Unlike chloramine-T, Pierce Iodination Reagent can be coated on glassware to enable solid-phase iodine-labeling. As a result, reducing agents are not necessary in the procedure.

Highlights:

  • Extremely stable and virtually insoluble in water
  • Solubility in chloroform permits plating aliquots of the reagent on the walls of the glass or plastic iodination vessels; plated vessels can be prepared in advance and stored in a dessicator
  • Allows rapid iodination of proteins in an aqueous reaction mixture containing radioactive Na125I
  • Side reactions are negligible
  • No reducing reagent is required because reactions are terminated by simply decanting the reaction solution away from the plated iodination reagent
  • Specific activities of 10,000cpm of 125I per microgram of protein and labeling efficiencies of 60% are easily achieved
  • Can be used to iodinate phenolic groups on crosslinkers or other protein modification reagents either before or after a protein, peptide or cell surface is reacted with the modification reagent
  • Small amounts of protein can be iodinated
  • More efficient than Chloramine-T or Lactoperoxidase
  • Iodinate phenolic groups on crosslinking reagents
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Iodination Reagent
Upon receipt store refrigerated and desiccated. Product shipped at ambient temperature.
Iodine-125
1 g
Pierce™
Radioisotope
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Manuals

User Guide: Pierce Iodination Reagent Version: MAN0016378 Rev. A.0 (17Nov2016) File size: 70.1 kB
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberXI324298 Certificate TypeCertificate of Analysis Date10/09/2022 Catalog Number28600
Lot NumberWF319559 Certificate TypeCertificate of Analysis Date02/07/2021 Catalog Number28600
Lot NumberVL308627 Certificate TypeCertificate of Analysis Date23/12/2020 Catalog Number28600
Lot NumberVJ309178 Certificate TypeCertificate of Analysis Date04/11/2020 Catalog Number28600
Lot NumberVH311208 Certificate TypeCertificate of Analysis Date03/09/2020 Catalog Number28600
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Product Title
Thermo Scientific™ Pierce™ Iodination Reagent (1,3,4,6-tetrachloro-3α,6α-diphenyl-glycoluril) > Iodination reagent powder; 1g

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