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Puromycin dihydrochloride, 98%, Thermo Scientific Chemicals
Description
It also exhibits antitumor activity in studies on brain tumor cells. Puromycin is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3¢-terminal end of aminoacyl-tRNA. It has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Information
• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis
Applications
• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.
Specifications
Specifications
| Type | Puromycin Dihydrochloride |
| Physical Form | Powder |
| Melting Point | 168°C to 170°C |
| Color | White |
| Quantity | 100 mg |
| Beilstein | 3853613 |
| Merck Index | 14,7943 |
| Solubility Information | Soluble in water |
| IUPAC Name | (2S)-2-amino-N-[(2S,3S,4S,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride |
| Formula Weight | 544.44 |
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Safety and Handling
- Puromycin dihydrochloride
- Warning
- Acute toxicity Category 4
- H302-Harmful if swallowed.
- P264-Wash face, hands, and anyexposed skin thoroughly after handling.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
- MIXTURE LIST-Contains : (S)-3-[[2-Amino-3-(4-methoxyphenyl)-1-oxo propyl]amino]-3-deoxy-N,N-dimethyladenosine dihydrochlorid
RUO – Research Use Only
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