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  6. Thermo Scientific Chemicals Puromycin dihydrochloride hydrate, 99%

Thermo Scientific Chemicals Puromycin dihydrochloride hydrate, 99%

Product Code. 10781691
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Quantity:
10 mg
50 mg
250 mg
Packaging:
Glass bottle

Description

Puromycin dihydrochloride hydrate, CAS # 58-58-2, is an aminoglycoside showing antibiotic, anti-neoplastic, and anti-protozoal activities. This compound also has the ability to inhibit protein synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Puromycin dihydrochloride hydrate is the hydrochloride salt form of puromycin and is an aminoglycoside with antibiotic activity isolated from the Streptomyces alboniger
• Puromycin dihydrochloride hydrate is a protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3’-terminal ends of aminoacyl-tRNA, inhibiting protein synthesis

Applications

• This compound shows anti-microbial, anti-protozoal, anti-trypanosomal, and anti-neoplastic activities and is also used as an antibiotic in cell culture
• It also reveals anti-tumor activity in studies on brain cancer cells
• This compound has been used to study transcriptional regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation
• It is active against gram-positive microorganisms, less active against acid-fast bacilli and gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae, and mammalian cells in in vitro studies.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 58-58-2
Molecular Formula C22H31Cl2N7O5
Molecular Weight (g/mol) 544.43
MDL Number MFCD00150080
InChI Key MKSVFGKWZLUTTO-MLYJQVMKNA-N
Synonym puromycin dihydrochloride
PubChem CID 131632508
IUPAC Name (2S)-2-amino-N-[(2S,3S,4S,5R)-5-[6-(dimethylamino)purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide;dihydrochloride
SMILES Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1

Specifications

Melting Point 168.0°C to 178.0°C
Assay Percent Range 98.5% min. (HPLC)
Packaging Glass bottle
Quantity 10 mg
Beilstein 26,IV,3704
Merck Index 15,8054
Solubility Information Solubility in water: soluble. Other solubilities: less soluble in ethanol
Formula Weight 544.44
Percent Purity 99%
Chemical Name or Material Puromycin dihydrochloride hydrate

Safety and Handling

compliance-icons
Product Identifier
  • Puromycin dihydrochloride hydrate
 Signal Word
  • Warning
 Hazard Category
  • Acute toxicity Category 4
 Hazard Statement
  • H302-Harmful if swallowed.
 Precautionary Statement
  • P301+P312-IF SWALLOWED: Call a POISON CENTER or doctor/physician/ if you feel unwell.

RUO – Research Use Only

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