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Pyr3, Tocris Bioscience™

Product Code. 18043782
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Quantity:
10 mg
50 mg
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Description

Selective TRPC3 blocker

Selective antagonist of the canonical transient receptor potential channel 3 (TRPC3). Inhibits TRPC3-mediated Ca2+ influx (IC50 = 0.7 μM) and suppresses activation of nuclear factor of activated T cells (NFAT). Inhibits hypertrophic responses in cardiomyocytes.

Chemical Identifiers

CAS 1160514-60-2
Molecular Formula C16H11Cl3F3N3O3
Molecular Weight (g/mol) 456.627
InChI Key RZHGONNSASQOAY-UHFFFAOYSA-N
Synonym pyr3, d0t7gc, pyr hplc, ethyl 1-4-trichloroprop-2-enamido phenyl-5-trifluoromethyl-1h-pyrazole-4-carboxylate, 1-4-2,3,3-trichloro-1-oxo-2-propen-1-yl amino phenyl-5-trifluoromethyl-1h-pyrazole-4-carboxylic acid, ethyl 1-4-2,3,3-trichloroacryloyl amino phenyl-5-trifluoromethyl-1h-pyrazole-4-carboxylate, ethyl-1-4-2,3,3-trichloroacrylamide phenyl-5-trifluoromethyl-1h-pyrazole-4-carboxylate
PubChem CID 56964346
IUPAC Name ethyl 1-[4-(2,3,3-trichloroprop-2-enoylamino)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
SMILES CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F

Specifications

Quantity 50 mg
Formula Weight 456.63
Percent Purity >98%
Chemical Name or Material Pyr3
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