missing translation for 'onlineSavingsMsg'
Learn More
Learn More
RGS14 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA530397
344.40 EUR valid until 2025-03-16
Use promo code "24070" to get your promotional price.
This item is not returnable.
View return policy
Description
Recommended positive controls: 293T, A431, Jurkat, Raji. Predicted reactivity: Mouse (91%), Rat (90%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
RGS14 is a member of the regulator of G-protein signaling family which contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. RGS14 attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. The resulting hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of RGS14 have been observed but have not been thoroughly characterized. Further, RGS14 acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism; plays a role in cell division; is required for the nerve growth factor (NGF)-mediated neurite outgrowth, and is involved in stress resistance. RGS14 protein may also be involved in visual memory processing capacity and hippocampal-based learning and memory.
Specifications
RGS14 | |
Polyclonal | |
Unconjugated | |
Rgs14 | |
rap1/rap2 interacting protein; RAP1/RAP2-interacting protein; Regulator of G-protein signaling 14; regulator of G-protein signalling 14; RGS14; RGSE; RPIP1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
10636, 51791 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.7 mg/mL | |
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7 | |
O43566, P97492 | |
Rgs14 | |
Recombinant fragment corresponding to a region within amino acids 1 and 193 of Human RGS14 | |
100 μL | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
Product Content Correction
Your input is important to us. Please complete this form to provide feedback related to the content on this product.
Product Title
RGS14 Polyclonal Antibody, Invitrogen™ > 100 μL; Unconjugated
Spot an opportunity for improvement?Share a Content Correction