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RO-3, Tocris Bioscience™

Product Code. 18095602
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Quantity:
10 mg
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Description

Selective P2X3 and P2X2/3 antagonist

Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.

Specifications

CAS 1026582-88-6
Molecular Formula C16H22N4O2
Quantity 10 mg
Synonym ro-3, ro3, 5-4,5-dimethoxy-2-methylethyl phenyl methyl-2,4-pyrimidinediamine, d0g8ni, 5-4,5-dimethoxy-2-propan-2-yl phenyl methyl pyrimidine-2,4-diamine
InChI Key PYNPWUIBJMVRIG-UHFFFAOYSA-N
SMILES CC(C)C1=CC(=C(C=C1CC2=CN=C(N=C2N)N)OC)OC
IUPAC Name 5-[(4,5-dimethoxy-2-propan-2-ylphenyl)methyl]pyrimidine-2,4-diamine
Molecular Weight (g/mol) 302.378
PubChem CID 11289644
Formula Weight 302.37
Percent Purity >98%
Chemical Name or Material RO-3
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