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  5. Ro 6842262, >98%, Tocris Bioscience™

Ro 6842262, >98%, Tocris Bioscience™

Product Code. 30000904
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent LPA1 antagonist

Potent LPA1 antagonist (IC50 = 25 nM). Exhibits >1,200-fold selectivity for LPA1 over LPA3. Attenuates NHLF human lung fibroblast cell proliferation and contraction in vitro. Also reduces plasma histamine levels in mouse LPA-challenge model. Orally bioavailable.

Chemical Identifiers

CAS 1396006-71-5
Molecular Formula C28H26N4O4
Molecular Weight (g/mol) 482.54
InChI Key PXQUHYSYFWQRMF-LJQANCHMSA-N
Synonym 1-4'-4-methyl-5-1r-1-phenylethoxy carbonylamino-1h-1,2,3-triazol-1-yl 1,1'-biphenyl-4-yl cyclopropanecarboxylic acid, 1-4'-4-methyl-5-r-1-phenyl-ethoxycarbonylamino-1,2,3 triazol-1-yl-biphenyl-4-yl-cyclopropanecarboxylic acid, 1-4'-4-methyl-5-r-1-phenyl-ethoxycarbonylamino 1,2,3 triazol-1-yl-biphenyl-4-yl-cyclopropanecarboxylic acid
PubChem CID 71265339
IUPAC Name 1-[4-[4-[4-methyl-5-[[(1R)-1-phenylethoxy]carbonylamino]triazol-1-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid
SMILES CC1=C(N(N=N1)C2=CC=C(C=C2)C3=CC=C(C=C3)C4(CC4)C(=O)O)NC(=O)OC(C)C5=CC=CC=C5

Specifications

Linear Formula C28H26N4O4
Solubility Information Soluble to 100mM in DMSO and to 20mM in ethanol
Quantity 10 mg
Formula Weight 482.53
Chemical Name or Material 1-[4′-[4-Methyl-5-[[[(1R)-1-phenylethoxy]carbonylamino]-1H-1,2,3-triazol-1-yl][1,1′-biph
Grade >98%
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