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SAHA, Tocris Bioscience™

Product Code. 30001593
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Class I and II HDAC inhibitor

SAHA inhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro. Activates autophagy. SAHA increases efficiency of transcription factor-induced reprogramming of mouse embryonic fibroblasts (MEF) to induced pluripotent stem cells (iPSC). Also enhances adeno-associated virus transduction of HeLa cells.

Chemical Identifiers

CAS 149647-78-9
Molecular Formula C14H20N2O3
Molecular Weight (g/mol) 264.325
InChI Key WAEXFXRVDQXREF-UHFFFAOYSA-N
Synonym vorinostat, saha, suberoylanilide hydroxamic acid, zolinza, n-hydroxy-n'-phenyloctanediamide, suberanilohydroxamic acid, n1-hydroxy-n8-phenyloctanediamide, saha cpd, vorinostat usan, octanediamide, n-hydroxy-n'-phenyl
PubChem CID 5311
ChEBI CHEBI:45716
IUPAC Name N'-hydroxy-N-phenyloctanediamide
SMILES C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO

Specifications

Quantity 50 mg
Formula Weight 264.32
Percent Purity >98%
Chemical Name or Material SAHA
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