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  8. SB 415286, Tocris Bioscience™

SB 415286, Tocris Bioscience™

Product Code. 30001275
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent, selective GSK-3 inhibitor

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Chemical Identifiers

CAS 264218-23-7
Molecular Formula C16H10ClN3O5
Molecular Weight (g/mol) 359.722
InChI Key PQCXVIPXISBFPN-UHFFFAOYSA-N
Synonym 3-3-chloro-4-hydroxyphenylamino-4-2-nitrophenyl-1h-pyrrole-2,5-dione, 3-3-chloro-4-hydroxyphenylamino-4-4-nitrophenyl-1h-pyrrole-2,5-dione, 3-3-chloro-4-hydroxyphenyl amino-4-2-nitrophenyl-1h-pyrrole-2,5-dione, 3-3-chloro-4-hydroxyanilino-4-2-nitrophenyl pyrrole-2,5-dione, 1h-pyrrol-2,5-dione, 3-3-chloro-4-hydroxyphenyl amino-4-2-nitrophenyl, tocris-1617, lopac-s-3567, d0n4wb, sb hplc
PubChem CID 4210951
IUPAC Name 3-(3-chloro-4-hydroxyanilino)-4-(2-nitrophenyl)pyrrole-2,5-dione
SMILES C1=CC=C(C(=C1)C2=C(C(=O)NC2=O)NC3=CC(=C(C=C3)O)Cl)[N+](=O)[O-]

Specifications

Quantity 10 mg
Formula Weight 359.73
Percent Purity >99%
Chemical Name or Material SB 415286
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