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STEMCELL Technologies SIS3

Activin/NODAL/TGF-β pathway inhibitor; Inhibits SMAD3

Brand: STEMCELL Technologies 73964

Product Code. 17130302

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Description

SIS3 (specific inhibitor of SMAD3) is a cell-permeable selective inhibitor of transforming growth factor β1 (TGF-β1)-dependent SMAD3 phosphorylation (IC₅₀ = 3 μM) and SMAD3-mediated cellular signaling (Jinnin et al.) SIS3 has no effect on SMAD2, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), or phosphoinositide 3-kinases
Facilitates the production of anterior ectoderm from mouse induced pluripotent stem cells (Oshima et al.)
Inhibits myofibroblast differentiation of normal human dermal fibroblasts (Jinnin et al.)

Specifications

Synonym	Smad3 inhibitor
Molecular Formula	C₂₈H₂₇N₃O₃

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