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Sotorasib, MedChemExpress

Product Code. 16454808
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Product Code. 16454808

Brand: Medchem Express HY114277

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Description

MedChemExpress Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.

Sotorasib (AMG-510) is a first-in-class, orally bioavailable, and selective KRAS G12C covalent inhibitor. Sotorasib irreversibly inhibits KRAS G12C by locking it in an inactive GDP-bound state. Sotorasib is the first KRAS G12C inhibitor in clinical development and leads to the regression of KRAS G12C tumors.

Specifications

Chemical Name or Material Sotorasib
Physical Form Powder
CAS 2296729-00-3
Color White
Quantity 10 mg
Purity Grade Notes Research
Molecular Formula C30H30F2N6O3
For Use With (Application) Cancer-Kinase/protease
Synonym AMG-510
Solubility Information DMSO : 50 mg/mL (89.19 mM; Need ultrasonic) ∣H2O : 33.33 mg/mL (59.46 mM; ultrasonic and adjust pH to 11 with NaOH)
SMILES O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1
Molecular Weight (g/mol) 560.59
Formula Weight 560.59
Percent Purity 98.0%
Grade Research
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Research purposes only

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