missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Unclassified Organic Compounds
  6. ST 034307, Tocris Bioscience™

ST 034307, Tocris Bioscience™

Product Code. 30000965
Click to view available options
Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

Chemical Identifiers

CAS 133406-29-8
Molecular Formula C10H4Cl4O2
Molecular Weight (g/mol) 297.94
InChI Key NTDHYMSVCBGQJF-UHFFFAOYSA-N
Synonym ST 034307
PubChem CID 867466
IUPAC Name 6-chloro-2-(trichloromethyl)chromen-4-one
SMILES C1=CC2=C(C=C1Cl)C(=O)C=C(O2)C(Cl)(Cl)Cl

Specifications

Linear Formula C10H4Cl4O2
Quantity 50 mg
Solubility Information Soluble to 100mM in DMSO and to 20mM in ethanol
Formula Weight 297.95
Percent Purity >98%
Physical Form Solid
Chemical Name or Material 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.