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  8. 30001394

SU 5402, Tocris Bioscience™

Product Code. 30001394
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Quantity:
1 mg
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This item is not returnable. View return policy

Description

Potent FGFR and VEGFR inhibitor

Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells.

Specifications

CAS 215543-92-3
Molecular Formula C17H16N2O3
Quantity 1 mg
Synonym 3-3-2-carboxyethyl-4-methylpyrrol-2-methylidenyl-2-indolinone, z-3-4-methyl-2-2-oxoindolin-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, chembl89363, 3-3-2-carboxyethyl-4-methylpyrrol-2-yl methylene-2-indolinone, 3-4-methyl-2-3z-2-oxo-1h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, 3-4-methyl-2-2-oxo-1,2-dihydro-3h-indol-3-ylidene methyl-1h-pyrrol-3-yl propanoic acid, pubchem22440, kdr kinase inhibitor, 5, d0a4xj
InChI Key JNDVEAXZWJIOKB-JYRVWZFOSA-N
SMILES CC1=CNC(=C1CCC(=O)O)C=C2C3=CC=CC=C3NC2=O
IUPAC Name 3-[4-methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
Molecular Weight (g/mol) 296.326
PubChem CID 5289418
Formula Weight 296.32
Percent Purity >95%
Chemical Name or Material SU 5402
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