Syntaxin 1 Polyclonal Antibody, Invitrogen™

Description

PA1-1042 detects Syntaxin 1 in rat, mouse and bovine samples. PA1-1042 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ∽33 kDa protein representing Syntaxin 1 in rat, mouse and bovine brain tissue samples. The PA1-1042 immunogen is a synthetic peptide corresponding to residues V(22) T V D R D R F M D E F F E Q V E E I R(41) of rat Syntaxin 1. This sequence is conserved in mouse, human and bovine. The PA1-1042 immunizing peptide (Cat. No. PEP-278) is available for use in neutralization and control experiments.

Syntaxin 1 is a small integral membrane protein that is abundantly expressed in neurons and neuroendocrine cells and thought to be implicated in the regulation of synaptic neurotransmitter release. Syntaxin 1 interacts with several other proteins important for synaptic function (SNAP 25, Munc 18). Syntaxin 1 is the main target of one of the Botulinum neurotoxins (BoNT/C1) which, however, cannot cleave the protein when complexed with its partner proteins in the fusion complex. Syntaxin 1 is an essential component of the neurotransmitter release machinery, and regulation of Syntaxin 1 expression levels is thought to contribute to the mechanism underlying learning and memory.