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Tadalafil, Tocris Bioscience™

Product Code. 30000939
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Potent and highly selective PDE5 inhibitor; orally bioavailable

Potent and highly selective PDE5 inhibitor (IC50 = 5 nM). Exhibits > 2000-fold selectivity for PDE5 over PDEs 1,2,3 and 4 and 1000-fold selectivity over PDE6. Reduces blood pressure in hypertensive rats. Also delays tumor growth in a mouse model via inhibition of MDSC-mediated immunosuppression. Orally bioavailable.

Chemical Identifiers

CAS 171596-29-5
Molecular Formula C22H19N3O4
Molecular Weight (g/mol) 389.411
InChI Key WOXKDUGGOYFFRN-IIBYNOLFSA-N
Synonym GF196960
PubChem CID 110635
ChEBI CHEBI:71940
SMILES CN1CC(=O)N2C(C1=O)CC3=C(C2C4=CC5=C(C=C4)OCO5)NC6=CC=CC=C36

Specifications

Linear Formula C22H19N3O4
Quantity 10 mg
Solubility Information Soluble to 100mM in DMSO
Formula Weight 389.4
Percent Purity >99%
Physical Form Solid
Chemical Name or Material (6R,12aR)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1',2':1,6]pyrido[3,4-b]
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